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一个令人感到希望的信息 [复制链接]

1#
以前看到过关于bayer bay 57-1293的药物研究信息
是发表在2002年的治疗疱疹新方式的专利
便一直没有看到进展,以为有失败或不进行研究了
今天又找到了一些
请参考
[tr=#e7e7de][tr=#e7e7de][tr=#ffffff]
muffin
Member since Sep-10-04
2483 posts
May-18-07, 06:59 PM (CST)
  
"update re: BAY 57-1293"

We hadn't seen any news about BAY 57-1293 in ages so I sent a note up to AiCuris a week or so ago. I received a response today. Excerpt from the response:
The compound is currently under development by AiCuris GmbH & Co. KG. Since pivotal studies are ongoing we are unable to disclose any information at the moment. It's nice to know that they are still in fact pursuing it. muffin ~ GHSV1 since 1986 <URL=> Paragraphs are a wonderful thing.

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2#

回复:一个令人感到希望的信息

也希望大家能够多关注以下,以下是以下关于bay 57 1293的信息
疱疹治疗新药研究进展

--------------------------------------------------------------------------------

[发布时间:20020411]
[来源:http://www.genetide.com/news/shownews.asp?id=111392]



    无环鸟苷Zovirax自上个世纪七十年代以来就一直是治疗口腔及生殖器疱疹的常规药物,尽管已得到多次改进,但仍然不适于某些患者的治疗。好消息是两大主要制药厂商目前已经研制出的三种新药可望最终解决这一难题。有关研究报告日前发表在《自然医学》杂志上。这三种新药丸虽然并不相同,但都属于解旋酶-引发酶抑制剂类,可以通过阻断DNA复制而攻击单纯疱疹病毒HSV。由于其作用机制和目前的常规抗病毒药不同,有关专家认为这可能有助于那些对无环鸟苷具有抗性的患者进行治疗。德国Bayer AG公司的动物实验表明其新药可以缩短愈合期,避免停药后出现反弹反应以及减少疱疹的发作次数和严重程度等。美国和加拿大Boehringer Ingelheim公司的研究也发现其新药对于治疗小白鼠口腔及阴道疱疹是完全有效的。另外,这些动物研究中均未出现任何严重的副作用。
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3#

回复:一个令人感到希望的信息

以下是一个关于HSV和药物研究和进展信息的网站
http://www.racoon.com/cgi-bin/dcforum/dcboard.cgi?az=list&forum=news
包括最新的信息并且和国际权威药厂有联络
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4#

回复:一个令人感到希望的信息

如果英语好的话,可以直接去问问情况!!
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5#

回复:一个令人感到希望的信息

另外一家公司的信息如下:
muffin
Guest
Nov-27-06, 05:04 PM (CST)
  
"does anyone remember Boehringer Ingelheim?"

   LAST EDITED ON Nov-27-06 AT 05:04 PM (CST)

BI is the other company that was researching the protease inhibitor (similar to BAY 53-1297). This article does reference herpes research specificaly but this relationship is something to monitor....
http://biz.yahoo.com/prnews/061127/dcm013.html?.v=73

Biota and Boehringer Ingelheim Complete US$102 Million License for HCV Program
Monday November 27, 10:14 am ET

MELBOURNE, Australia, Nov. 27 /PRNewswire/ -- Biota Holdings Limited (ASX: BTA - News) announced today that they have entered into a worldwide research collaboration and licensing agreement with Boehringer Ingelheim to develop and commercialize Biota's novel nucleoside analogues designed to treat Hepatitis C Virus (HCV) infections and potentially other diseases.

Under the terms of the agreement, Biota is eligible to receive payments up to US$102 million based on products achieving certain clinical, regulatory and commercialization milestones, including an initial technology access fee and research support. In addition, Biota would receive royalties on future sales of licensed products marketed by Boehringer Ingelheim. Specific terms of the agreement were not disclosed.

"Today's agreement with Boehringer Ingelheim is further validation of Biota's antiviral drug discovery capabilities and our ability to consistently deliver valuable candidates to global pharmaceutical companies," said Peter Cook, Biota's Chief Executive Officer. "We are delighted to be working with Boehringer Ingelheim, a premier pharmaceutical company, who is internationally recognized as one of the world leaders in the research and development of antiviral therapeutics." Both companies reiterated the importance of this agreement as a joint effort to come one step closer to a potential treatment for HCV infections for which there is a large unmet medical need due to the limited treatment options available.

Under the terms of the agreement, Biota is responsible for drug discovery research and Boehringer Ingelheim is responsible for worldwide development of potential compounds and their commercialization. Biota and Boehringer Ingelheim will be equally represented on the Joint Research Committee to oversee and coordinate the activities of the program.

About Boehringer Ingelheim

The Boehringer Ingelheim group is one of the world's 20 leading pharmaceutical companies. Headquartered in Ingelheim, Germany, it operates globally with 143 affiliates in 47 countries and approximately 37,500 employees. Since it was founded in 1885, the family-owned company has been committed to researching, developing, manufacturing and marketing novel products of high therapeutic value for human and veterinary medicine.

In 2005, Boehringer Ingelheim posted net sales of euro 9.5 billion while spending almost one fifth of net sales in its largest business segment, Prescription Medicines, on research and development.

For more information please visit http://www.boehringer-ingelheim.com.

About Biota

Biota is a leading antiviral drug development company based in Melbourne, with key expertise in respiratory diseases, particularly influenza. Biota developed the first-in-class neuraminidase inhibitor, zanamivir, and subsequently marketed by GlaxoSmithKline (GSK) as Relenza. Relenza is currently being stockpiled by a number of national governments for defense against avian influenza. Biota receives royalties from sales of Relenza.

Recent Biota research breakthroughs have included a series of candidate drugs aimed at Respiratory Syncytial Virus (RSV) or bronchiolitis, subsequently licensed to MedImmune Inc. Biota has Phase I clinical trials underway with Human Rhinovirus (HRV). In addition, Biota has key partnerships with Sankyo; for the development of second generation influenza antivirals (called LANI or Long Acting Neuraminidase Inhibitors) and with Inverness Medical (Thermo Electron); Biota developed the FLU OIA?influenza diagnostics, currently marketed in the US.

(TM)Relenza is a registered trademark of the GlaxoSmithKline group of companies.

瓼LU OIA & FLU OIA A/B are registered trademarks of Thermo Electron Corporation.

*Further information available at http://www.biota.com.au.
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6#

回复:一个令人感到希望的信息

这里的战友有心的话,可以自告奋勇的为大家翻译啊!
当然我也会这样做的!!!!
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7#

回复:一个令人感到希望的信息

谢谢 Bayer

看了你推荐的那个网站,由于自己英文水平有限,只明白了个大概,还不知道理解的对不对,很开心,因为研究实验还是在进行的!只要这样就好,我们就还有希望!
不过目前没有任何人敢给什么明确的承诺,也许明年就可以根治,也许20年后还是根治不了!当然希望越快越好!
希望你以后继续把国际上最新的动态带给我们,我可以等10年,10内可以有办法根治我就满足了,你看,我的要求不算高吧,呵呵!
希望大家都保持好心态,开心生活!
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8#

回复:一个令人感到希望的信息

这里。我亲自问了两个大家最关心的问题
以下是他们的回复,虽然结果不尽如人意,但是真的感谢他们的及时回复
http://racoon.com/dcforum/news/1276.html
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